Order Prometrium capsules online from a U.S. pharmacy

Product Name	Prometrium
Dosage	100 mg, 200 mg
Active Ingredient	Progesterone (micronized)
Form	Oral Capsules (soft gelatin)
Description	Prescription progesterone used for secondary amenorrhea and to reduce the risk of endometrial hyperplasia in postmenopausal women receiving estrogen therapy.
How to Order Without Prescription	Prescription required in the USA; consult your licensed healthcare provider.

Prometrium is the U.S. brand of micronized progesterone available as oral capsules. In the United States, Prometrium is a prescription medication. It is commonly used to treat secondary amenorrhea and to lower the risk of endometrial hyperplasia in postmenopausal women who are taking estrogen as part of menopausal hormone therapy. The capsules are typically available in 100 mg and 200 mg strengths, allowing clinicians to tailor therapy based on each patient’s goals and clinical profile.

Progesterone is a naturally occurring hormone. Micronized formulations are designed to enhance absorption when taken by mouth. In the U.S. market, both brand-name Prometrium and FDA-approved generics of micronized progesterone are dispensed by retail and mail-order pharmacies. If your prescriber does not require a specific brand, generic progesterone capsules may offer a cost-saving alternative while delivering a therapeutically equivalent dose.

Prometrium cost

The out-of-pocket price for Prometrium (micronized progesterone) can vary widely in the USA depending on your insurance plan, the pharmacy’s pricing, whether you are dispensed brand-name or generic, and the quantity per fill. Many patients use manufacturer savings cards or pharmacy discount programs to reduce costs.

Typical strengths are 100 mg and 200 mg capsules. A 30-capsule supply can range from affordable generic prices to higher brand-name costs. Patients with commercial insurance may pay only a copay, while those paying cash can often reduce expenses with pharmacy coupons. For those using estrogen therapy and requiring monthly cycles of progesterone, a 90-day mail-order fill may provide better per-capsule pricing. Always ask your pharmacist to check whether a lower-cost generic is available and if your prescriber allows substitution.

To maximize savings in the U.S.:

• compare pharmacy prices (retail vs. mail-order)
• ask about FDA-approved generic progesterone capsules
• use applicable savings programs or discount cards
• talk with your clinician about a 90-day supply if appropriate
• verify coverage with your insurance plan formulary

Because pricing is dynamic, your final cost is determined at the time of dispensing based on your pharmacy, plan benefits, and any applicable discounts.

Where can I buy Prometrium in the USA?

 In the United States, Prometrium is available at licensed community pharmacies and through accredited mail-order services with a valid prescription from a licensed healthcare professional. After your prescriber sends in your Rx, you can choose home delivery or in-store pickup. Many patients prefer mail-order pharmacies for long-term therapy because of convenience, potential savings, and automatic refill reminders.

Our platform helps you connect with trusted U.S. pharmacy partners that dispense authentic medications from licensed manufacturers. You’ll receive professional counseling from pharmacists who can answer questions about dosing, timing, side effects, and how Prometrium fits into your overall treatment plan.

If you have difficulty visiting a physical pharmacy or prefer the simplicity of online refills, mail delivery is an excellent option. However, remember that Prometrium requires a prescription in the USA. If you don’t currently have one, schedule a visit or telehealth appointment with a licensed clinician to discuss whether Prometrium is appropriate for your needs.

Prometrium USA

Getting Prometrium in the United States is straightforward with a valid prescription. Your prescriber will determine the appropriate strength (100 mg or 200 mg) and dosing schedule, depending on your indication: treatment of secondary amenorrhea or use with estrogen therapy to help protect the endometrium. Once the prescription is issued, place your order through your preferred pharmacy and arrange pickup or delivery.

What is Prometrium?

 Prometrium is a brand of micronized progesterone taken by mouth. Progesterone is a naturally occurring steroid hormone produced primarily by the ovaries and, during pregnancy, by the placenta. In clinical practice, progesterone plays a vital role in regulating the menstrual cycle, supporting the endometrium, and balancing the effects of estrogen on uterine tissue.

Prometrium capsules are indicated in the U.S. for:

• treating secondary amenorrhea
• reducing the risk of endometrial hyperplasia in non-hysterectomized postmenopausal women receiving conjugated estrogens

Healthcare professionals may also use progesterone in other contexts based on clinical judgment (off-label), such as luteal-phase support in certain fertility settings. Any off-label use should be guided by an experienced clinician who can tailor the therapy to the patient’s medical history and goals.

Prometrium for menopausal hormone therapy

 When estrogen is used alone in women who still have a uterus, it can increase the risk of endometrial hyperplasia. Adding a progestogen such as micronized progesterone helps counter this risk by opposing estrogen’s proliferative effects on endometrial tissue. Prometrium offers a bioidentical progesterone option, meaning its molecular structure matches endogenous human progesterone.

Many prescribers select Prometrium 200 mg at bedtime for 12 days of each 28-day cycle in postmenopausal women receiving daily estrogen therapy. This cyclical approach helps maintain endometrial safety while also supporting comfort and sleep in some patients. Always follow the specific regimen prescribed by your clinician.

Patients should be counseled about potential risks associated with menopausal hormone therapy, particularly when estrogen is combined with a progestogen. These risks can include cardiovascular events, breast tenderness, and other hormone-related effects. Shared decision-making with your clinician is essential to ensure that benefits outweigh potential risks based on your health status.

Why progesterone is important during estrogen therapy

For individuals with an intact uterus, unopposed estrogen can lead to excessive thickening of the uterine lining. Introducing a progestogen reduces this risk by promoting a secretory transformation of the endometrium, thereby lowering the chance of hyperplasia. Prometrium provides a well-studied, bioidentical progesterone option in capsule form that is commonly incorporated into menopausal treatment plans when estrogen is used.

Prometrium in fertility care and luteal support (off-label)

 Micronized progesterone can play a role in fertility management and luteal-phase support in select clinical scenarios. While Prometrium capsules are not specifically labeled for infertility, clinicians may prescribe progesterone—by mouth, vaginally, or via injection—to support the luteal phase or early pregnancy under expert supervision. Patients should follow the exact regimen recommended by their reproductive endocrinologist or gynecologist, as dosing and formulations differ by protocol and clinical context.

Is Prometrium a “progestin”?

In everyday usage, “progestin” often refers to synthetic molecules with progesterone-like activity. Prometrium contains micronized progesterone, which is bioidentical to the body’s own progesterone. Although both progesterone and synthetic progestins act on progesterone receptors, they can have different pharmacologic profiles and side-effect patterns. Your clinician can explain which option best aligns with your medical history and treatment goals.

Micronized progesterone formulations: oral vs. vaginal

 Progesterone is available in multiple formulations. Prometrium is an oral, micronized capsule designed for enhanced absorption. Vaginal formulations (gels, inserts, capsules) deliver progesterone locally to the uterine area and are often chosen for certain fertility protocols. The decision between oral and vaginal routes depends on your indication, tolerance, and clinician preference. Some patients find that taking oral Prometrium at bedtime minimizes daytime drowsiness.

Whichever formulation is chosen, it’s important to take progesterone exactly as directed and to report any unusual bleeding, persistent headaches, visual changes, or signs of possible clotting events to your healthcare team immediately.

Prometrium for secondary amenorrhea

 Secondary amenorrhea refers to the absence of menstrual periods in someone who previously had regular cycles. Prometrium can be used to induce a secretory transformation of the endometrium, after which withdrawal bleeding typically occurs upon discontinuation. The aim is to mimic the hormonal changes of a normal cycle and help maintain uterine health under a clinician’s guidance.

Depending on the underlying cause of amenorrhea, your clinician may order tests before starting therapy and will select a dosing schedule appropriate for your situation. It is important to follow up as recommended so that your care plan can be adjusted based on your response.

Mechanism of action

 Progesterone binds to progesterone receptors found in reproductive tissues, the central nervous system, and other organs. In the endometrium, progesterone counteracts estrogen-induced proliferation, promoting differentiation and converting the lining into a secretory state. This mechanism supports uterine health, regulates cycles, and contributes to the protection of the endometrium when estrogen therapy is used.

Progesterone may also exert effects on sleep and mood in some patients. Because Prometrium can cause drowsiness, clinicians often recommend taking it at bedtime. Individual responses vary, and patients should report any unusual daytime sedation or cognitive effects to their prescriber.

Safety

As with any hormone therapy, careful assessment of risks and benefits is essential. When estrogen is combined with a progestogen (including progesterone), data from large studies have shown increased risks for certain events such as cardiovascular disorders, breast tenderness, and other hormone-related effects. These risks must be weighed against potential benefits like symptom management and endometrial protection, and treatment should be used at the lowest effective dose for the shortest appropriate duration.

Additional cautions include history of thromboembolic disorders, stroke, myocardial infarction, liver impairment, hormone-sensitive malignancies, and undiagnosed abnormal genital bleeding. Your clinician will evaluate personal and family history to determine if Prometrium is appropriate for you and may recommend regular monitoring as needed.

Dosing and administration

 The dosing of Prometrium should be individualized by a licensed healthcare professional. Common U.S.-labeled regimens include:

• Prevention of endometrial hyperplasia in postmenopausal women on estrogen therapy: 200 mg orally at bedtime for 12 days of each 28-day cycle.
• Treatment of secondary amenorrhea: 400 mg orally daily at bedtime for 10 days (or as directed by your clinician).

Because Prometrium may cause drowsiness or dizziness, bedtime dosing is commonly recommended. Swallow the capsules whole with a glass of water; do not crush or chew. Always follow your prescriber’s exact instructions, which may differ based on your medical needs.

Cycle planning and timing

 Your clinician may recommend a cyclic schedule that integrates Prometrium with estrogen therapy or sets a specific start day for amenorrhea treatment. Keep a calendar of your dosing days and expected withdrawal bleeding. Contact your clinician if you experience heavy or unexpected bleeding, or if bleeding does not occur when anticipated.

Missed dose and overdose guidance

If you miss a dose of Prometrium, take it as soon as you remember unless it is nearly time for the next dose. If it is close to your next scheduled dose, skip the missed dose and resume your normal schedule. Do not double up to make up for a missed dose. If you suspect an overdose or experience severe symptoms such as loss of consciousness, severe dizziness, trouble breathing, or intense confusion, seek emergency medical attention right away.

Storage and handling

Store Prometrium at room temperature away from excessive heat, moisture, and light. Keep capsules in their original container and out of reach of children and pets. Do not use Prometrium past the expiration date printed on the label. Dispose of unused or expired medication according to your pharmacist’s instructions or community guidelines.

How to take Prometrium

 Take Prometrium exactly as prescribed by your healthcare professional. Because it can cause sedation, bedtime administration is usually preferred. Avoid activities that require alertness (such as driving or operating machinery) if you feel drowsy after taking Prometrium. If you are combining Prometrium with estrogen therapy, follow your cycle schedule closely and keep all follow-up appointments.

Do not share your medication with others and do not use Prometrium for any condition not prescribed by your clinician. If your symptoms change or you develop new concerns, contact your prescriber for guidance.

Pregnancy and breastfeeding

Prometrium is not indicated for use in pregnancy for the labeled indications. If you become pregnant while taking Prometrium, notify your prescriber promptly for individualized advice. Progesterone can be present in breast milk; discuss potential risks and benefits with your clinician if you are breastfeeding or plan to breastfeed. The decision to continue, adjust, or discontinue therapy should be made in partnership with your healthcare professional.

Pharmacist’s tips for taking Prometrium

 Because Prometrium can cause drowsiness, take it at bedtime unless your prescriber directs otherwise. If you are on a cyclic regimen with estrogen, set calendar reminders for start and stop days to stay on track. Report any unusual vaginal bleeding, persistent headaches, visual changes, chest pain, shortness of breath, swelling, or leg pain immediately. These could be signs of rare but serious adverse events that require urgent evaluation.

Inform your care team about all current medications, supplements, and herbal products. Some substances can influence progesterone metabolism or increase sedation. Your pharmacist can help screen for interactions and suggest the best time of day to take your other medicines relative to Prometrium.

Note: Historically, certain Prometrium capsule formulations have contained peanut oil. If you have a peanut allergy, alert your clinician and pharmacist so they can verify the product’s current excipients and determine a safe alternative if necessary.

Safety Precautions

 Do not use Prometrium if you have a known hypersensitivity to progesterone or any component of the capsule. Inform your clinician if you have a history of:

• blood clots, stroke, heart attack, or clotting disorders
• liver disease or impaired liver function
• undiagnosed abnormal vaginal bleeding
• hormone-sensitive cancers (e.g., breast, uterine)
• severe depression or other significant mood disorders
• peanut allergy or other severe allergies

Avoid alcohol or limit intake if you experience increased drowsiness with Prometrium. Use caution with activities requiring mental alertness until you know how the medication affects you.

Prometrium side effects

 Many people tolerate Prometrium well, but side effects may occur. They are often mild and improve as your body adjusts. If any side effect is persistent or concerning, contact your prescriber. Seek emergency care for symptoms of a serious allergic reaction such as hives, swelling of the face or throat, severe dizziness, or difficulty breathing.

Commonly reported side effects include:

• drowsiness or dizziness (often reduced by bedtime dosing)
• breast tenderness
• headache
• bloating or abdominal discomfort
• nausea
• mood changes or irritability
• breakthrough bleeding or spotting

Serious adverse effects are uncommon but require immediate attention. These may include signs of blood clots (chest pain, sudden shortness of breath, coughing up blood, swelling or pain in one leg), stroke symptoms (severe headache, trouble speaking, sudden vision changes, weakness on one side), jaundice, severe abdominal pain, migraines with aura, or severe depression.

Side effects by treatment setting

During menopausal hormone therapy (with estrogen):

• breast discomfort or tenderness
• mild fluid retention or bloating
• headache or mood changes
• irregular bleeding patterns, especially in the first months

In the treatment of secondary amenorrhea:

• drowsiness, dizziness, or fatigue
• nausea or mild gastrointestinal upset
• changes in menstrual timing, volume, or cramping after withdrawal
• breast tenderness or fullness

When progesterone is used off-label for fertility support (as directed by a specialist):

• somnolence or lightheadedness
• mood changes or irritability
• spotting or discharge changes (route-dependent)
• breast sensitivity

Reporting side effects

 If you suspect you are experiencing a side effect from Prometrium, contact your prescriber or pharmacist. You can also report adverse events to the FDA MedWatch program at 1-800-FDA-1088 or online at www.fda.gov/medwatch.

Interaction of Prometrium with other medicines

 Progesterone metabolism may be affected by substances that influence CYP3A4 and other hepatic enzymes. Additionally, Prometrium can increase sedation when combined with other central nervous system depressants. Always tell your clinician and pharmacist about all prescription drugs, over-the-counter medicines, vitamins, and herbal supplements you take.

Medicines and substances that may interact with Prometrium include (not a complete list):

• strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin)
• strong CYP3A4 inducers (e.g., rifampin, carbamazepine, phenytoin, St. John’s wort)
• barbiturates (e.g., phenobarbital, butalbital)
• benzodiazepines and other sedatives/hypnotics (e.g., clonazepam, lorazepam, zolpidem)
• opioids and other CNS depressants, including sodium oxybate (GHB)
• valproic acid and other antiepileptic drugs
• anticoagulants (e.g., warfarin): monitoring may be advisable as directed by your clinician

This list is not exhaustive. Keep an updated medication list and share it with every healthcare professional who treats you. Your prescriber may adjust doses, change medications, or schedule follow-up monitoring to help avoid interactions.

Recommendations from our specialists

 If Prometrium is part of your treatment plan, coordinate closely with your prescriber to confirm the right strength and dosing schedule. Consider setting reminders to help you follow a cyclic regimen, and contact your clinician if you notice any unexpected bleeding or other concerning symptoms. If you anticipate travel or schedule changes, request refills early to avoid therapy interruptions. Our pharmacy partners dispense authentic medications and can provide delivery options across the USA.

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